Los Angeles is the busiest departure port in California. It operates year-round and offers a wide range of itineraries from a 3 night Mexico cruise to a 100+ night world cruise.
Mexico (3 to 10+ nights) is the most common itinerary, with cruises along the west coast (4 to 7+ nights) being the second-most common. Hawaii takes the bronze for popularity (14+ nights).
On top of these options, there are occasional Alaska roundtrips (14+ nights) and Panama Canal cruises that end on the US east coast (14+ nights).
Finally, as a world-class city, world cruises and segments are often bookable from here.