While San Diego isn’t as busy a cruise port as LA, it holds its own. It operates year-round and offers a wide range of itineraries from a 3 night Mexico cruise to a 90+ night Pacific circle cruise.
Mexico (3 to 10+ nights) is the most common itinerary, with cruises along the west coast (4 to 7+ nights) being the second-most common. Hawaii takes the bronze for popularity (14+ nights).
On top of these options, there are Panama Canal cruises that end on the US east coast (14+ nights).
Finally, for something really special, there are also a few world cruise segments or month-long cruises that explore various South Pacific islands.